A new emergence of pemphigus vulgaris - Corrected Proof , Pemphigus is an autoimmune disease with intraepidermal bullous lesions, which may affect the oral, genital, or ocular mucosa and the skin. It usually affects people between the ages of 50 and 60 years and is generally evenly distributed between the sexes. The triggering mechanism that initiates the immune response is not known yet. Pemphigus vulgaris is the most common form of pemphigus. The lesions are often insidious and localized. Persistent, painful ulcers and a burning sensation, which affect the appetite, are the clinical findings in pemphigus vulgaris. Mucosal and skin surfaces may be involved in severe cases. Moreover, the conjunctival, pharyngeal, and laryngeal mucosa may be involved, along with extensive skin lesions. The diagnosis of pemphigus vulgaris is made from mucosal biopsies and subsequent histologicalexamination. Furthermore, fluorescent techniques are used for the detection and localization of the tissue-bound antibodies. Nikolsky’s sign is highly indicative of pemphigus that might be absent in some patients with pemphigus vulgaris. The process of destruction of the intercellular connections (desmosomes) of the epithelial cells (acantholysis) has been observed in these cases. Antibodies against desmoglein 3, generally IgG, can be found tissuebound, at the level of the spinous cell membrane and circulating in the blood of patients with active pemphigus vulgaris. , http://bit.ly/Y8uKPl

A new emergence of pemphigus vulgaris - Corrected Proof , Pemphigus is an autoimmune disease with intraepidermal bullous lesions, which may affect the oral, genital, or ocular mucosa and the skin. It usually affects people between the ages of 50 and 60 years and is generally evenly distributed between the sexes. The triggering mechanism that initiates the immune response is not known yet. Pemphigus vulgaris is the most common form of pemphigus. The lesions are often insidious and localized. Persistent, painful ulcers and a burning sensation, which affect the appetite, are the clinical findings in pemphigus vulgaris. Mucosal and skin surfaces may be involved in severe cases. Moreover, the conjunctival, pharyngeal, and laryngeal mucosa may be involved, along with extensive skin lesions. The diagnosis of pemphigus vulgaris is made from mucosal biopsies and subsequent histologicalexamination. Furthermore, fluorescent techniques are used for the detection and localization of the tissue-bound antibodies. Nikolsky’s sign is highly indicative of pemphigus that might be absent in some patients with pemphigus vulgaris. The process of destruction of the intercellular connections (desmosomes) of the epithelial cells (acantholysis) has been observed in these cases. Antibodies against desmoglein 3, generally IgG, can be found tissuebound, at the level of the spinous cell membrane and circulating in the blood of patients with active pemphigus vulgaris. , http://bit.ly/Y8uKPl , via Dental Teach " Daily Dental Info " http://www.facebook.com/photo.php?fbid=587007114657175&set=a.578110838880136.1073741835.110664842291407&type=1