Effects of glucosamine on tooth pulpal nociceptive responses in the rat , Abstract: Background/purpose: d-Glucosamine hydrochloride (DGL) has a variety of biological activities and is noted as a nutritional supplement that is effective for improvement and care of various disorders, such as osteoarthritis and atherosclerosis. Although, it has been reported that DGL has a significant pain relief effect in treating osteoarthritis, little is known about its effect on dental pain. The applicability of DGL as a medicament to control pain in pulpalgia has not been reported. In this study, using an in vitro rat mandible-inferior alveolar nerve preparation (jaw-nerve preparation), the effect of DGL on nociceptive responses in the tooth pulpal nerve was examined.Materials and methods: The effect of DGL on nociceptive responses for 20 male Wistar albino rats was evaluated using an in vitro jaw-nerve preparation. Bradykinin (BK), used as a chemical nociceptive stimulant, was applied near the exposed tooth pulp. Sixty seconds after BK application, the surface of the exposed pulp was treated with DGL solution or physiological saline (control).Results: The nerve firing rate was 2.06±0.21Hz (n=10) after 5 minutes of saline application, and 0.76±0.16Hz (n=10) after 5 minutes of DGL application. The DGL group showed significantly lower nerve firing rate than the control group.Conclusion: BK-induced nociceptive responses were significantly suppressed by direct application of DGL. Our results suggest that DGL might have a pain relief effect in dental pain. , http://bit.ly/11JRSXG

Effects of glucosamine on tooth pulpal nociceptive responses in the rat , Abstract: Background/purpose: d-Glucosamine hydrochloride (DGL) has a variety of biological activities and is noted as a nutritional supplement that is effective for improvement and care of various disorders, such as osteoarthritis and atherosclerosis. Although, it has been reported that DGL has a significant pain relief effect in treating osteoarthritis, little is known about its effect on dental pain. The applicability of DGL as a medicament to control pain in pulpalgia has not been reported. In this study, using an in vitro rat mandible-inferior alveolar nerve preparation (jaw-nerve preparation), the effect of DGL on nociceptive responses in the tooth pulpal nerve was examined.Materials and methods: The effect of DGL on nociceptive responses for 20 male Wistar albino rats was evaluated using an in vitro jaw-nerve preparation. Bradykinin (BK), used as a chemical nociceptive stimulant, was applied near the exposed tooth pulp. Sixty seconds after BK application, the surface of the exposed pulp was treated with DGL solution or physiological saline (control).Results: The nerve firing rate was 2.06±0.21Hz (n=10) after 5 minutes of saline application, and 0.76±0.16Hz (n=10) after 5 minutes of DGL application. The DGL group showed significantly lower nerve firing rate than the control group.Conclusion: BK-induced nociceptive responses were significantly suppressed by direct application of DGL. Our results suggest that DGL might have a pain relief effect in dental pain. , http://bit.ly/11JRSXG , via كل يوم معلومة من طب الأسنان http://www.facebook.com/photo.php?fbid=443972922352314&set=a.438993006183639.1073741843.157162584366684&type=1